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The slow, continuous leak of trapped varenicline from these compartments back to the plasma membrane continuously desensitizes surface 42 receptors, directly counteracting the receptor upregulation caused by chronic nicotine exposure (Govind et al, 2017)
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Shuter J, Kim RS, An LC, Abroms LC
But very quickly, this initial freshness is embellished with a contrasting sweetness, thanks to the tonka bean
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