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The European Medicines Agencys Pharmacovigilance Risk Assessment Committee also concluded that NAION should be listed as a very rare side effect of semaglutide medications after reviewing clinical trials, post-marketing surveillance, non-clinical data, and published medical literature

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Cumulative incidence estimates are based on time from randomization to first EAC-confirmed cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke with non-CV death modeled as competing risk using the Aalen-Johansen estimator

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