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171 MottaweaW.ChiangC.-K.MuhlbauerM.StarrA

While both scenarios likely contribute to immune tolerance, it is generally believed that hot tumors may respond better to immune checkpoint inhibitors (ICIs) than cold tumors because the former have pre-existing cytotoxic cells potentially capable of recognizing tumor derived neoantigens.47 For cold tumors, on the other hand, antitumor immunity is likely abrogated at a much earlier stepmaking this subtype potentially more challenging to treat with ICIs

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