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Sample Size and Power Calculations As no data are available in the literature on the efficacy of varenicline for gradual cessation in patients with COPD who are poorly motivated to quit, our sample size calculation was based on the cessation rates observed for abrupt cessation in patients with COPD motivated to quit smoking receiving a combination of varenicline and smoking cessation counseling

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"It's funny how you always hear people saying that classic parent attitude of, 'I brought you into this world, I gave you life!' You know, it's just, I think, completely the opposite

SS was measured using three questions developed by Pierce et al