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Quinones lead to irreversible thiol- S -alkylation and protein aggregation to deplete protein thiols in the proteome in vivo (Liebeke et al., 2008)

A cutoff value of 10.2 nmol/mg for GSH was identified, and the area under the ROC curve was 0.913, with a sensitivity of 90.2% and a specificity of 81.8%, demonstrating significant predictive capability in differentiating between the resistant group and sensitive group