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Genetic variants in nicotine addiction and alcohol metabolism genes, oral cancer risk and the propensity to smoke and drink alcohol: A replication study in India

In the Netherlands, tobacco plants were first cultivated in 1615, in Germany in Suhl in the Henneberger Land in 1659, in the Mark Brandenburg in 1676, and by 1697 tobacco was also being cultivated in the Palatinate and Hesse

Principal among the rising causes of death were cardiovascular disease and lung cancertwo major consequences of cigarette smoking, which is the only risk factor that is both entirely avoidable and actively promoted

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