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Nicotine and Tobacco Research 6(Suppl 1):S55-S65

MR is based on three key assumptions: 1) the genetic variants used as instruments for the exposure must be valid and robustly associated with the exposure, 2) there should be no measured or unmeasured confounding of the association between the genetic instrument and the outcome, and 3) the variants should have no independent effect on the outcome other than through the exposure of interest 17

A : E-cigarettes (also referred to as e-cigs, e-hookahs, mods, vape pens, vapes, tank systems, and electronic nicotine delivery systems) are battery-operated devices used to heat and aerosolize a liquid in order to deliver nicotine, flavorings, and other chemicals that users inhale

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