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In addition, within the adolescent M1, maladaptive changes in 5-HT signaling and 5-HT 1A activity after nicotine or fluoxetine exposure may potentiate hyper-responsiveness to dopaminergic drugs and prime adolescent vulnerability for future substance abuse

This synergy between consumer preferences and marketing strategies has, over time, established the 20-cigarette pack as the industry benchmark

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Infrequent : chest discomfort, chills, edema, influenza-like illness, pyrexia