Gamma-Glu-Gluelicited [Ca 2+ ] i increases were detected when it was applied at a concentration of 10 M on both GluN2A- and GluN2B-expressing C6 cells (Figures 3B,C)
Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: Modulation by the Nrf2/Trx axis
In this protective role, ATF4 drives the expression of the chaperone heat shock protein family A (Hsp70) member 5 (HSPA5), which in turn stabilizes and enhances the activity of GPX4, thereby inhibiting ferroptotic cell death ( In ferroptosis resistant melanoma cells, CHAC1 was shown to be upregulated by NRF2 independent from ER stress signaling alongside the Aldo-Keto Reductase Family 1 Member C1 (AKR1C1) capable of degrading lipid radicals (Gagliardi et al., 2019)
Giannakou M, Saltiki K, Mantzou E, Loukari E, Philippou G, Terzidis K et al (2018) The effect of obesity and dietary habits on oxidative stress in Hashimotos thyroiditis