how to give yourself a semaglutide shot in the stomach Administer Your Own Injections at Home How and Where to Inject

Semaglutide (Wegovy, Ozempic): Overview: Class: GLP-1 receptor agonist Administration: Once-weekly subcutaneous injection Average Weight Loss: 10-15% of body weight FDA Approval: Ozempic (2017), Wegovy (2021) Available Doses: Starting: 0.25 mg weekly Escalation: 0.5 mg, 1.0 mg, 1.7 mg Maximum: 2.4 mg weekly for weight loss Clinical Trial Results (STEP-1): Average weight loss: 14.9% over 68 weeks 5% weight loss: 86.4% of participants 10% weight loss: 69.1% of participants 15% weight loss: 50.5% of participants Brand Options: Wegovy: FDA-approved for weight loss, $1,349/month Ozempic: FDA-approved for diabetes, prescribed off-label for weight loss, $969/month Compounded semaglutide: $199-$599/month, same active ingredient Pros: Highly effective (10-15% weight loss) Proven cardiovascular benefits (20% reduction in heart attacks/strokes) Extensive safety data (on market since 2017) Once-weekly convenience Affordable compounded option available Cons: Nausea in 44% of users (usually improves) Brand-name very expensive without insurance Periodic shortages affecting availability Best For: Patients needing to lose 20-50 pounds Those with cardiovascular disease (proven benefits) Budget-conscious patients (compounded at $199/month) Anyone wanting highly effective, proven medication Tirzepatide (Zepbound, Mounjaro): Overview: Class: Dual GIP/GLP-1 receptor agonist Administration: Once-weekly subcutaneous injection Average Weight Loss: 15-22% of body weight FDA Approval: Mounjaro (2022), Zepbound (2023) Available Doses: Starting: 2.5 mg weekly Escalation: 5 mg, 7.5 mg, 10 mg, 12.5 mg Maximum: 15 mg weekly for weight loss Clinical Trial Results (SURMOUNT-1): Average weight loss: 22.5% over 72 weeks (15 mg dose) 5% weight loss: 96% of participants 10% weight loss: 89% of participants 15% weight loss: 78% of participants 20% weight loss: 63% of participants Brand Options: Zepbound: FDA-approved for weight loss, $1,069/month Mounjaro: FDA-approved for diabetes, prescribed off-label for weight loss, $1,069/month Compounded tirzepatide: $349-$699/month, same active ingredient Pros: Most effective weight loss medication available (15-22% loss) Lower nausea rates than semaglutide despite higher potency Best chance of achieving 20%+ weight loss Affordable compounded option available Cons: More expensive than semaglutide (both brand and compounded) Newer medication (less long-term safety data than semaglutide) Cardiovascular outcomes trial still ongoing Best For: Patients needing maximum weight loss (50+ pounds) Those who plateaued on semaglutide Anyone wanting most effective medication available Patients who can afford $349/month for compounded option Liraglutide (Saxenda, Victoza): Overview: Class: GLP-1 receptor agonist Administration: Daily subcutaneous injection Average Weight Loss: 5-8% of body weight FDA Approval: Victoza (2010), Saxenda (2014) Available Dose: Escalate to 3.0 mg daily Clinical Trial Results (SCALE): Average weight loss: 8.0% over 56 weeks Significantly less effective than newer GLP-1s Cost: $1,400/month No compounded options available Pros: Proven safety record (on market since 2010) Cons: Daily injections (less convenient) Much less effective than semaglutide or tirzepatide More expensive than more effective options Largely obsolete now that better options exist Verdict: Rarely prescribed anymore

The Joi + Blokes GLP-1 page includes this disclosure directly on the product page

The last bucket is the diversifiers and maybe the institutional more frequently are in this bucket

This happens when your body adapts to your new, lower weight and reduced calorie intake, a process known as metabolic adaptation