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Many studies have discussed the interaction between alcohol consumption and smoking, and previous studies have mainly focused on cancers of the upper aerodigestive tract.9, 45, 46 Some studies have investigated the interaction between light drinking and light smoking, but evidence supporting it has not been found, which is consistent with our findings.22, 24, 29, 39 Studies have shown an interaction effect between drinking and smoking on upper aerodigestive tract cancers, including oral, pharyngeal, laryngeal, and esophageal cancers.7, 8, 9, 22, 24, 29, 31, 39, 47, 48 In a meta-analysis,8 the synergistic consumption of both alcohol and tobacco was associated with an increased probability of developing oral squamous cell carcinoma (OR, 5.37

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But when it got bigger, and it wasnt a family anymore, thats when it began to run less efficiently