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Not only did he tolerate the many comics who impersonated him, but encouraged the caricatures endlessly supplied by the likes of Rich Little and frequent guest impersonator Will Jordan, the man largely responsible for the iconic line, "We've got a really big shoo." However, despite regular appearances by cutting-edge comedians like George Carlin and Richard Pryor, contemporary music acts such as Janis Joplin, as well as a pre-"Sesame Street" appearance by Jim Henson's Muppets, Sullivan's variety show was becoming regarded as old hat in the changing landscape of television during the late-1960s

To understand the intracellular kinetics of CR production, we monitored the levels of the metabolite in CR hi cells over time

Past 8 , 19291940 (2012)

Bero, L