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A researcher who miscalculates concentration by a factor of two administers double the intended dose across an entire study, invalidating weeks of data collection
For example, programmed death ligand 1 (PD-L1), which is highly expressed in numerous human tumor cells, antagonizes T cell activation signals by binding to its receptor, programmed cell death 1(PD-1), on activated T cells (197)
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Chronic wounds exemplify this challenge, sharing pathophysiological features with systemic chronic infections, including persistent microbial colonization, immune evasion, and biofilm formation
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