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This is also why strains like Jack Herer are commonly used to support people who want to enjoy the benefits of weed without experiencing high levels of paranoia or hallucinations

Therefore, we aim to test a secondary hypothesis that baseline nicotine metabolite ratio (NMR) will moderate the experimental treatment effect, such that the benefit of dose titration will be greater in those participants who are rapid metabolizers of nicotine, and the final titrated dose they reach will be higher on average than the slow metabolizers