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These microbial and transcriptomic changes exacerbated inflammatory injury in early COPD, as corroborated in murine models, highlighting the interplay between smoking, airway microbiota, and disease pathogenesis [15]

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We added this incremental increase of 2 percentage points to the previously approved estimate in the CY 2023 PFS final rule that 12 percent of clinicians who participated in MIPS for the CY 2021 performance period/2023 MIPS payment year will submit data for the quality performance category through MVP reporting in the CY 2023 performance period/2025 MIPS payment year (88 FR 79443)

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