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Measures Socio-demographic variables and moderators Socio-demographic measures included age, education level, ethnicity, and smoking status, and were assessed using previously validated measures adapted from the International Cigarette Packaging Study surveys and the Brazil National International Tobacco Control (ITC) survey

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The biosynthesis of cannabinoids follows the plastidial methylerythritol phosphate (MEP) pathway that has been described elsewhere and is summarized in Fig