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2000 titled Initial symptoms of nicotine dependence in adolescents. However, this time frame varies significantly based on several factors, including the frequency of use, the method of consumption (such as smoking or using smokeless tobacco), and genetic predisposition

And while contesting the evidence that smoking caused disease and that nicotine was the addictive drug in cigarettes, the cigarette companies secretly accepted these facts since the 1950s (cancer) and 1960s (addiction)

Irritates the lungs, leading to coughing, excess mucus, chest discomfort, and poorer lung function

Table 1 also reveals several interesting findings regarding the effect of different variables affecting smoking