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The most effective anti-obesity medicines available are orlistat (Xenical), phentermine-topiramate (Qsymia), lorcaserin (Belviq), bupropion-naltrexone (Contrave), Liraglutide (Saxenda) and Semaglutide (Wegovy) and Tirzepatide (Mounjaro)

Ephedra Also commonly referred to as ephedrine, this ingredient has a reputation for being straight-up dangerous, and rightfully so

Addressing these gaps will facilitate precision medicine by enabling treatment strategies tailored to individual profiles [136], ultimately improving clinical outcomes (Table 2)

It has been suggested that the vagus nerve mediates the aversive effects of GLP-1, as ip injection of exendin-4 induces CFA in vagotomised but not sham-operated rats [151]