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Ricky Wilkerson, 49, of Lebanon, Tenn., is in a stop-smoking program at the Veterans Administration hospital in Nashville

2002 MMWR 51 : 300303 Clemmesen J

Quitting smoking is so hard because of the complex interplay between physical addiction to nicotine and the psychological habits formed around tobacco use, as studied in an article by the Centers for Disease Control and Prevention titled Why Quitting Smoking Is Hard. Physically, nicotine creates dependence by altering brain chemistry, leading to withdrawal symptoms such as irritability, cravings, and anxiety when a person tries to quit

Riddick M, Marshall J, Parker R (2017) Systems and apparatus for reducing tobacco-specific nitrosamines in dark-fire cured tobacco through electronic control of curing conditions