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The makers of Puff Bar, which the Food and Drug Administration ordered to stop selling flavored e-cigarette products in July 2020, recently announced that they were returning to the market with tobacco-free nicotine. The company claims the nicotine is crafted from a patented manufacturing process, not from tobacco, and is purer than tobacco-containing or derived nicotine without the residual impurities of tobacco-derived nicotine, according to Puff Bars website
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Tobacco smoke contains over 7,000 chemicals, including hundreds of known carcinogens and reactive oxygen species (ROS) that cause oxidative stress and directly activate inflammatory pathways in the lungs, vascular endothelium, and throughout the body