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These can be considered in three general groups, namely primary immuno-dysregulation, decrease of the mucosal barrier and states of heightened antigenic sensitivity (see below)

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Finally, individuals with extensive or multiple prior resections may be at risk of short gut syndrome with consequent malabsorptive diarrhea, dehydration, weight loss, and electrolyte disturbances

Notably, the City of Denver enacted a ban on the sale of most flavored tobacco products , including flavored e-cigarettes (vaporizers), menthol cigarettes, and flavored cigars and smokeless tobacco, which took effect in 2025 (with some sources indicating March 18, 2025)