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Most studies evaluating the first generation somatostatin analogs have demonstrated neutral to mild adverse effects (51)
The most common issues include nausea, constipation , dizziness , fatigue , and bloating
This included: Reconciling top-down and bottom-up estimates Cross-checking revenues, volumes, and pricing assumptions Incorporating expert insights to validate segment splits and adoption rates This multi-angle validation yielded the final market size
However, recent studies have reported malignant behavior of tumors that show local recurrence and metastasis [2, 6]
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