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Implications By collecting and analyzing the clinical data of 3196 patients with undiagnosed HUA at baseline from 2010 to 2021 in Dalian Municipal Central Hospital of China, and by constructing a Cox proportional risk model, adjusting for relevant influencing factors, and further stratifying the analysis, this study clarified that smoking was an independent risk factor for the occurrence of HUA, and was independent of gender, whether a woman was menopausal, BMI and alcohol consumption, with large and innovative sample size