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After the initial 36 weeks, participants lost 21.1% of their body weight After the following 52 weeks, the tirzepatide group lost another 6.7% of their body weight, while the placebo group regained 14.8% Through the 88-week study, the tirzepatide group lost 26% of their body weight Tirzepatide had a similar safety profile in SURMOUNT-3 and SURMOUNT-4 as its previous trials, most commonly citing mild-moderate gastrointestinal issues

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The goal is to be gentle and deliberate

The down-regulation of NCOA4 in cells inhibits ferritin autophagy and ferroptosis, whereas NCOA4 overexpression increases ferritin degradation and promotes ferroptosis, suggesting that NCOA4 is involved in the interaction between autophagy and ferroptosis (43)