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These products pose significant risks to oral health, including gum disease, tooth decay, and oral cancer, stemming from prolonged exposure to carcinogens and irritants [3]

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These alterations contribute to systemic inflammation by increasing the production of pro-inflammatory cytokines, including interleukin (IL)-1, IL-6, IL-8, IL-13, tumor necrosis factor-alpha (TNF-), and transforming growth factor-beta 1 (TGF-1) [24]

Smoking is a known risk factor for the disease, which is characterized by fat buildup in the liver and possible progression to more serious liver inflammation