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Oral cancer oral sores that do not heal persistent oral pain or discomfort white, red, or speckled patches in the mouth difficulty eating and speaking swelling of the jaw or face a lump in the neck or throat difficulty moving the jaw or tongue numbness of the tongue or lips loose teeth vocal changes Oral cancer has tobacco use of any type heavy alcohol use infection with sexually transmitted HPV, specifically HPV 16 sun exposure, which can cause lip cancer The risk of developing oral cancer also increases with age, and most frequently occurs in people over 40 years old