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The first is the direct effect of nicotine on the brain nicotine increases activity in areas associated with attention and releases dopamine, creating a sense of reward

The throat is lined with delicate tissue designed to remain moist and protected by mucus

A prospective Rotterdam Study found that the incidence of Alzheimer's disease is more than double for smokers as compared to non-smokers and the Honolulu Heart Program (a longitudinal cohort study) also found more than twice the risk for Alzheimer's disease among medium and heavy smokers as compared to non-smokers

It is more convenient to use and is easily available