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One article found an increased incidence of aspiration pneumonia among GLP-1 users compared to non-users reporting a hazard ratio of 1.33 (95%CI 1.021.74, p = 0.036) (Australian Diabetes Society, National Association of Clinical Obesity Services, Gastroenterological Society of Australia, and Australian and New Zealand College of Anaesthetists n.d.)

In chronic renal failure patients on dialysis, due to reduced dietary intake, limited endogenous synthesis, and clearance by hemodialysis, plasma free carnitine concentration can drop by 70%

The FAK-paxillin pathway further supports fibroblast migration and collagen organization across tendons, ligaments, and muscles

On the other, some longevity researchers point to data showing that IGF-1 suppression is a common feature of exceptionally long-lived populations, including certain centenarian cohorts