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Mitochondrial respiratory chain complex I and III are considered to be the main producers of ROS, the impairment of which contribute to mitochondrial ROS formation (Ashkar et al., 2022)
Additionally, the trial was conducted in patients with type 2 diabetes rather than individuals with obesity alone, which may influence generalizability
Smoking also reduces saliva production that normally helps neutralize refluxed acid and clear it back to the stomach
A 2017 study published in the Journal of Cosmetic Dermatology found that oral glutathione supplementation showed modest improvements in skin brightness over 12 weeks, but topical studies remain limited
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