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Funding Research reported in this publication is supported by the National Institute on Drug Abuse of the National Institutes of Health under Award Number R01DA054993

The large sample size, extended follow-up period, and robust adjustment for confounders strengthen the validity of these findings

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Also, because GLP-1 drugs engage the brain's reward circuitry the same system that governs not just craving but everyday motivation prolonged use could, in theory, dampen motivational drive in some people