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Nat Rev Endocrinol, 2018, Vol 14(7), pp 390403

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According to Camp, "skin care products cant restore fat to areas that have lost it, but they can help protect skin from environmental factors that reduce collagen and elastin, namely UV radiation, and help maintain current levels." To help firm the skin, Camp recommends using a daily sunscreen to limit UV-induced degradation of elastin and collagen

[1] [2] It remains under clinical investigation, and all available safety data derive from controlled trial settings rather than real-world use