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In Herbal Medicine: Biomolecular and Clinical Aspects 2nd edition

The LC was interfaced with an Orbitrap Exploris 480 mass spectrometry (Thermo Fisher Scientific, Bremen, Germany) via a Proxeon nanospray source using a Pico-Tip emitter (360 m OD 20 m ID, 10 m tip

Male SpragueDawley (SD) rats weighing 200 20 g were obtained from the Animal Experiment Center of the Fourth Military Medical University (Xian, China) and housed in a specific pathogen-free animal facility

The distinction between cagrilintide and survodutide reflects broader principles in peptide pharmacology: single-target selectivity allows cleaner mechanistic investigation, while multi-receptor agonism produces integrated metabolic effects that better mimic physiological complexity