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Statistical analysis Cox proportional hazards models were used to examine the associations between cigar status and mortality outcomes based on underlying causes of death from the 10th revision of International Statistical Classification of Diseases and Related Health Problems (ICD-10) [21], reported as hazard ratios (HRs, with 95% confidence intervals, CI) with never smokers as the referent group

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Cigarette smoking remains the leading cause of preventable death and disease in the United States, accounting for 490,000 premature deaths per year