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My protocol was straightforward: Retatrutide: 4 mg per week, subcutaneous injection (abdomen), every Saturday morning AOD-9604: 0.3 mg per day, subcutaneous injection (abdomen), every morning before eating Duration: 16 weeks of the combined stack Diet: High protein (90 to 100 grams daily), moderate carbs, 30 to 40 grams of healthy fats Activity: Walking 5 days a week, light resistance training 2 days Within the first two weeks of adding AOD-9604, I noticed my midsection felt different
One of the RCTs found significant mean improvements in Clinical Global Impressions-Improvement (CGI-I) score and cellular methylation capacity, but not in the Aberrant Behaviour Checklist (ABC), Social Responsiveness Scale (SRS) or GSH metabolism, with those who had the lowest methionine status at baseline (suggesting impaired methylation capacity) significantly more likely to respond to supplementation
Methionine, in turn, is the source of S-adenosylmethionine (SAM), a central methyl group donor needed to synthesise many hormones and neurotransmitters
