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Nicotine Dependence, Depression, and Gender: Characterizing Phenotypes Based on Withdrawal Discomfort, Response to Smoking, and Ability to Abstain

Key considerations for using edibles for constipation relief: choose edibles with minimal artificial ingredients and added sugars, consider full-spectrum products that include minor cannabinoids like CBG, maintain consistent timing to help establish digestive rhythm, and monitor portion sizes to avoid overconsumption that might disrupt gut function

Investor Relations & Media Contact Matt Kreps Investor Relations 22nd Century Group [email protected] 214-597-8200

As smoking is increasingly unacceptable and restricted, it is possible that some of the patients experienced social pressure because of their smoking habit and, therefore, refused to participate or continue in the study