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A reduction in exposure to free radicals and other oxidative stressors should, therefore, lead to a reduction in GSH depletion and a concomitant reduction in the expression of oxidative stress response genes, including those involved in maintaining the GSH pool

The main effect of these is increasing the surface area, which boosts both flavour and vapour production

There are 3 ways to communicate these massive changes: 1) HONEST: Vaping increased AND Smoking dropped 2) PLAUSIBLE: Smoking dropped BECAUSE vaping increased 3) DISHONEST: Smoking dropped, BUT vaping increased #3 is profoundly dishonest: It denies product substitution

Other e-cigarette ingredients, particularly flavoring agents, independently carry risks associated with heart and lung diseases in animals, and negative effects have been shown in studies of individuals exposed to chemicals in commercially available products, he said