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Their activity is regulated by various factors, including the RANKL-RANK-OPG signaling pathway, estradiol, various cytokines and calciotropic hormones ( Cigarette smoking creates an imbalance in bone turnover, which leads to lower bone mass and decreased bone mineral density and makes bones prone to osteoporosis and fractures

Additional correction for the effects of head-motion used the ICA-AROMA tool (ICA-based Automatic Removal Of Motion Artefacts

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