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Size-exclusion chromatography yielded monodisperse protein that was suitable for cryo-EM grid preparation and screening (Supplementary Fig

This is a common concern for patients considering GLP-1 receptor agonists like semaglutide (Wegovy, Ozempic) and tirzepatide (Zepbound, Mounjaro)

While HDAC modulators (inhibitors/activators) show therapeutic potential for RA, current single-target agents are limited by poor isoform selectivity, off-target toxicity, and inadequate attenuation of RAs multi-pathway pathology

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