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In the same study, a weaker association with global DNA methylation levels was found near DNMT1 , which encodes the key enzyme for DNA methylation maintenance (described in Section DNA Methylation

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An additional feature of e-cigarettes that is now often manipulated is nicotine type, based on the ratio of the R- and S-nicotine isomers: synthetic nicotine contains a mixture of both R- and S-nicotine, whereas traditional tobacco-derived nicotine contains primarily S-nicotine 15