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The sweet spot for most trials is between 3g and 6g daily, with or without a loading phase (5-10 days of higher creatine intake before reducing to around 3-6g daily).2 3 Some studies even use 10g of creatine, showing both muscle-building effects and the ability to improve cognition and general wellness.4 5 Those are pretty large doses, which is why so many creatine supplements are sold in powder form instead of as capsules

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HNE as an inducer of COX-2