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Stop smoking, kid

Tobacco smoking affects the serum levels of many coadministered drugs due to induction of cytochrome P450 (CYP) hepatic enzymes (especially CYP1A2) by polycyclic aromatic hydrocarbons and non-nicotinic chemical constituents, resulting in more rapid metabolism and clearance of certain drugs

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An interesting study demonstrating the effects of smoking in an obese rat model of NAFLD was performed by Azzalini et al , who exposed obese Zucker rats to cigarette smoke and observed activation of pathways, inflammatory mediators, immunohistochemistry, and changes in liver histology