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However, because higher insulin concentrations are required to suppress gluconeogenesis than to inhibit glycogenolysis (i.e., the breakdown of glycogen), or increase glycogen synthesis, gluconeogenically derived glucose-6-phosphate can be diverted into hepatic glycogen even during mild hyperinsulinemia [87,123]

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Outcome analysis: risk of depression Pooled effect estimate Across the 19 included studies, all authors reported an effect estimate for incident or worsening depression-related adverse events associated with GLP-1 receptor agonist (GLP-1 RA) exposure