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Lateral Medullary Syndrome (Wallenberg Syndrome), paresthesias Paresthesias Subjective cutaneous sensations (e.g., cold, warmth, tingling, pressure, etc.) that are experienced spontaneously in the absence of stimulation

A has a neurotoxic effect, which can lead to neuronal degeneration, death, apoptosis, and decrease in the number of synapses and ultimately lead to cognitive impairment and behavioral abnormalities (Li W

FoxO1, a downstream target of the PI3K/Akt pathway, is phosphorylated by Akt and retained in the cytoplasm, thereby preventing its inhibition of target gene expression in the nucleus of POMC neurons [17]

*These statements have not been evaluated be the Food and Drug Administration