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Further, because the only large-scale trials of GLP-1 agonists have been conducted in obese or overweight study populations, we dont yet know if these drugs affect body composition in normal-weight individuals in an equivalent manner
Studies in the field of accelerated aging have established a link between PARP activation and impaired mitochondrial health, which is associated with reduced NAD + levels resulting from PARP hyperactivation 158
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Resmetirom is the only medication currently FDA-approved to treat MASH, and while results from different studies are not comparable linearly, nothing in resmetirom's pivotal trial suggests that it is superior to tirzepatide
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