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Senescent erythrocytes are characterized by loss of surface area and volume [66], increased cell density [67], reduced deformability [68], cation loss [69], membrane desialylation [70], enzymatic dysregulation [69], oxidative stress [71], hemichrome abundance [69], elevated levels of glycated hemoglobin [72], reduced expression of phagocytosis-inhibiting CD47 [73], altered protein 4.1a/protein 4.1b ratio [74], etc

Varisco points out that the drug injections ended up reducing the number of drinks people had at a time versus the number of days that people drank

Missing several weeks in a row can mean stepping back to a lower dose while your body re-adjusts