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Additionally, low dosing may not provide enough testosterone to reverse the metabolic or cognitive issues associated with hypogonadism

The disease is characterized by disproportionate and symmetrical accumulation of subcutaneous fat in the extremities

5.3 Drug application The routine therapeutic drugs for osteoporosis include BPs, selective estrogen receptor modulators, and parathyroid hormone analogs, matched to the intervention of osteoporosis under different etiologies, fulfilling ideal efficacy while accompanied by certain adverse effects (33)

These mechanistic interactions are supported by preclinical and early-phase human data, and their relative contributions in clinical practice continue to be studied