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J Cell Biol 113: 13311340 CummingsBS,AngelesR,McCauleyRB,LashLH (2000) Role of voltagedependent anion channels in glutathione transport into yeast mitochondria

A study observed that the levels of endothelial progenitor cells and vascular inflammation in patients treated for 24 weeks using Darunavir were indistinguishable from non-infected patients, while those exposed to Rilpivirine showed signs to endothelial cell dysfunction (Echeverria et al

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However, further in vitro assays showed a different pharmacological profile, since although the effect on cAMP was notable, we did not observe additional significant effects on -arrestin recruitment activation, therefore providing a similar profile than other non-peptidic agonists like CHU-128 and TT-OAD2