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Unlike current PD treatments that primarily alleviate symptoms, bilirubin's multi-target nature may allow simultaneous intervention in multiple disease progression pathways, achieving multi-efficacy with a single agent. However, translating bilirubin into clinical therapy still faces challenges: determining the optimal treatment window, selecting administration routes (especially efficient blood-brain barrier penetration), evaluating long-term safety, and establishing individualized dosing regimens all require in-depth research