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A notable case is a 45-year-old female patient who previously experienced intense fatigue and rapid weight gain during periods of stress or dietary variation

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These limitations have driven decades of research into smaller molecules that can activate TrkB signaling with better pharmacokinetic properties

Although fewer synovial macrophages are present in OA than in rheumatoid arthritis, they are crucial for the production of pro-inflammatory cytokines, such as IL-6 and TNF- 11