3rd generation glp 1 GLP-1, GIP & GLP-3 for Weight Loss: What They Are & Why They Work 💉 From Semaglutide → Tirzepatide

Alternative GLP-1s Check if Wegovy or Saxenda have different formulary status Saxenda is a preferred drug on TRICAREmay have lower copay and easier approval 9

At therapeutic doses, GLP-1 drugs cross the blood-brain barrier and dampen dopamine signaling in the brains core reward center, making addictive substances less rewarding

A 2025 study in Aging Cell confirmed these findings in both normal epithelial and fibroblast cell lines, identifying hTERT upregulation as the primary mechanism in normal cells (4)

Treatment with survodutide also showed meaningful metabolic improvements, including reductions in waist circumference, a key predictor of cardiometabolic risk